Database : HANSEN Search on : CAMUNDONGOS ENDOGAMICOS CBA [Subject descriptor] References found : 9 [refine] Displaying: 1 .. 9   in format [Detailed]

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Id: 18225 Author: Ebenezer, G. J; Norman, G; Joseph, G. A; Daniel, S; Job, C. K Title: Drug resistant-Mycobacterium leprae--results of mouse footpad studies from a laboratory in south India ..- Source: s.l; s.n; 2002. 12 p. tab. Abstract: Out of 265 biopsies of leprosy patients received at the Experimental Pathology Laboratory of Schieffelin Leprosy Research and Training Centre from 1987 to 1997 for evaluating resistant strains of M. leprae, using the mouse footpad technique, 49 showed resistant strains of M leprae to varying concentrations of dapsone, rifampicin and clofazimine. 23 (47%) of these were from a control area. With 369 skin-smear positive multibacillary (MB) patients as the risk group (denominator), 23 (6.23%) were resistant to one or more drugs. 18 (4.88%) had dapsone resistance, 5 (1.36%) were resistant to rifampicin and 9 (2.44%) had resistance to low concentrations of clofazimine (0.0001%). Out of the 23 biopsies with drug resistance from the control area, primary dapsone resistance was seen in 7 (30%) biopsies and secondary dapsone resistance in 11 (48%). Primary rifampicin resistance was seen in 4 (17.4%) patients, secondary rifampicin resistance in 1 (4.35%) and primary clofazimine resistance in 7 (30%). 3 (13%) of the strains showed secondary clofazimine resistance. One biopsy had resistant strains to all the three drugs. In a control area where properly supervised effective multidrug therapy (MDT) was regularly administered over the years, the emergence of drug resistance is negligible. It may not be the case if the content, duration and regularity of the drug regimen were not satisfactory. Aware of the possible shortcomings in mass administration of MDT, it is emphasized that mouse footpad studies on drug resistance should be made available at least in endemic areas where the incidence of the disease has not changed despite good MDT coverage in order to monitor the emergence of drug resistance. Research into molecular biological identification of drug resistant-M.leprae should be intensified. These steps would help to institute timely measures to check the spread of any drug-resistant organisms in the community. (AU). Descriptors: Clofazimina/PD Dapsona/PD Farmacorresistência Bacteriana Farmacorresistência Bacteriana Múltipla Índia Hansenostáticos/*PD Hanseníase/*DT/MI Camundongos Camundongos Endogâmicos CBA Testes de Sensibilidade Microbiana Mycobacterium leprae/*DE Rifampina/PD Limits: HUMANO ANIMAL MASCULINO FEMININO Location: BR191.1; 09179/S

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Id: 13962 Author: Maslov, A. K; Luzhnova, S. A; Kalyanina, O. V Title: Effects of horseradish root on functional activity of phagocytes, total blood cell count, and state of the liver in mice with experimental leprosy ..- Source: s.l; s.n; 2002. 3 p. tab. Abstract: Therapy of experimental leprosy with dried and grated horseradish root administered perorally in a dose of 300 mg/kg mixed food and treatment with purified horseradish peroxidase increased myeloperoxidase activity of blood neutrophils, enhanced antimicrobial functions of phagocytes, decreased leukocytosis, normalized total blood cell count, and produced no adverse effects on the functional state of the liver in mice. (AU). Descriptors: CONTAGEM DE CELULAS SANGUINEAS RELACAO DOSE-RESPOSTA A DROGA HANSENIASE/imunol HANSENIASE/fisiopatol FAGOCITOS/ef drogas FAGOCITOS/imunol CAMUNDONGOS ENDOGÂMICOS CBA FIGADO/ef drogas FIGADO/imunol FIGADO/fisiopatol RAIZES DE PLANTA/quim ARMORACIA/quim Limits: ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 09146/s

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Id: 13475 Author: Das, P. K; Ibrahim, A. A; Binkhuysen, F; Thi Hué, P; Qui, T. H; Rangarajan R;; Ruitenberg EJ Title: The use of subcellular components of BCG for studying host-Mycobacterium interaction in relation to leprosy ..- Source: s.l; s.n; Jul.-Aug. 1982. 19 p. ilus, tab, graf. Abstract: Mycobacterium bovis-BCG was sonified and centrifuged at 90,000g for 2h to obtain pellet (P90) and supernatant (S90), and bacilli broken by chilled X-press were fractionated into cell wall (CW), plasma membrane and cytosol. Rabbits were immunized with P90, S90 and whole sonified-broken BCG. The antigenic make-up of these antisera. These analysed by cross-immunoelectrophoresis using the antisera. These subcellular preparations were also used for detecting circulating antibodies in the sera of 45 leprosy patients by Ouchterlony´s technique and immunoelectrophoresis. Although there were many antigenic determinants common to more than one fraction, some components were found in only one fraction. Furthermore, different leprosy patients showed different patterns of antibody response to the antigens in the different fractions. In addition, these fractions were also used to assess cell-mediated immunity in mice sensitized with lyophilized whole BCG as well as with irradiated Mycobacterium. it was found that BCG, intraperitoneally injected, engedered different specifically antigen-sensitized populations of lymphocytes in the spleen and lymph node. Moreover, a certain degree of antigenic cross-reactivity was observed between BCG and M. leprae, possibly at the T-cell level. In vitro experiments suggested that the CW stimulated B cells, indicating a mitogenic ctivity leading to polyclonal activation. Finally, in vitro priming experiments established that these subcellular fractions could sensitize human peripheral lymphocytes, and upon secondary culture all primed cells were able to respond to homologous preparations but not always to heterologous preparations, thus offering a means to distinguish antigens of interest from those antigenically less complicated fractions at the T-cell level.(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol CAMUNDONGOS ENDOGÂMICOS CBA MYCOBACTERIUM BOVIS/imunol IMUNOELETROFORESE BIDIMENSIONAL HANSENIASE/imunol ANTICORPOS ANTIBACTERIAS/anal ANTIGENOS DE BACTERIAS/anal TATUS FRACOES SUBCELULARES/imunol Limits: HUMANO ANIMAL FEMININO CAMUNDONGOS COELHOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01556/s

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Id: 13220 Author: Rees, R. J; McDougall, A. C;; Weddell, A. G Title: The testis in mice infected with Mycobacterium leprae ..- Source: s.l; s.n; feb. 1975. 7 p. ilus, tab. Abstract: Following inoculation either locally or intravenously with Mycobact. leprae of human origin, the histopathology and bacteriology of the testis in experimental mice is described. Normal mice, and mice rendered immunologically deficient by thymectomy and whole-body irradiation, were studied. Attention is drawn to a heavy bacillation of the testis in mice from both groups. Bacilli were found in and beneath the tunica albuginea, but mainly in interstitial cells and in macrophages surrounding the tubules. The percentage of solidly staining bacilli was high, and globi were frequent. The study showed that the testis in mice is particularly favourable for the lodgement and multiplication of Mycobact. laprae following either local or intravenous inoculation. The significance of this in relation to the metabolism of the leprosy bacillus and to the frequent occurrence of testicular damage in the lepromatous male patient is discussed. This work was supported by grants to A. G. M. Weddell and A. C. McDougall from the Medical Research Council and the British Leprosy Relief Association (LEPRA).(AU). Descriptors: HANSENIASE/microbiol HANSENIASE/patol IMUNOSSUPRESSAO CAMUNDONGOS ENDOGÂMICOS CBA CAMUNDONGOS NUS MYCOBACTERIUM LEPRAE/isol TESTICULO/microbiol TESTICULO/patol TIMECTOMIA IMUNIDADE/ef rad Limits: ANIMAL MASCULINO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 01582/s

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Id: 13199 Author: Chandi, S. M; Job, CK Title: The early cellular response to M. leprae ..- Source: s.l; s.n; jul. 1978. 13 p. . Abstract: The ultrastructural changes that develop in mouse peritoneal macrophages from 10 minutes up to 14 weeks after exposure to Mycobacterium leprae are presented. Phagocytosis occurred by a process of engulfment by cytoplasmic processes and incorporation into a phagosome, into which lysosomal enzymes were subsequently introduced. Electron transparent zones (E.T.Z.) were not observed around phagocytosed bacilli in this study, however discrete droplets of lipid-like material appeared in the cytoplasm of macrophages, between 2 and 4 weeks after ingestion of the micro-organisms. Phagosomes with double limiting membranes were observed in macrophages harvested as early as 40 minutes after exposure to M. leprae, contrary to the observations of Evans and Levy (1972).(AU). Descriptors: HANSENIASE/fisiopatol CAMUNDONGOS ENDOGÂMICOS CBA MYCOBACTERIUM LEPRAE/cresc FAGOCITOSE FATORES DE TEMPO MACROFAGOS/microbiol MACROFAGOS/ultraest Limits: ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 02143/s

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Id: 11593 Author: Maslov, A. K; Kalyanina, O. V Title: Effect of peroxidase on the development of experimental leprosy in mice after intraplantar infection ..- Source: s.l; s.n; 2000. 3 p. tab. Descriptors: IMUNIDADE HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS CBA MYCOBACTERIUM LEPRAE PEROXIDASE PEROXIDASE Limits: ANIMAL Location: BR191.1; 08416/s

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Id: 10975 Author: Maslov, A. K; Luzhnova, S. A Title: Effects of peroxidase therapy on functional state of the liver and phagocytes and blood cell counts in mice with experimental leprosy ..- Source: s.l; s.n; 2000. 5 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE FIGADO FIGADO CONTAGEM DE CÉLULAS SANGUINEAS PEROXIDASE DO RABANO SILVESTRE MICROSCOPIA ELETRONICA PEROXIDASE FAGOCITOS FAGOCITOS CAMUNDONGOS ENDOGAMICOS CBA Limits: ANIMAL CAMUNDONGOS Location: BR191.1; 07330/s

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Id: 10005 Author: Peake, P. W; Britton, W. J; Davenport, M. P; Roche, P. W; McKenzie, K. R Title: Analysis of B-cell epitopes in the variable C-terminal region of the mycobacterium leprae 70-kilodalton heat shock protein ..- Source: s.l; s.n; 1993. 7 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTICORPOS MONOCLONAIS FORMAÇAO DE ANTICORPOS LINFOCITOS B ELISA EPITOPOS GENES BACTERIANOS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS ENDOGAMICOS CBA CONFORMAÇAO MOLECULAR DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MAPEAMENTO DE PEPTIDIOS PROTEINAS RECOMBINANTES PROTEINAS RECOMBINANTES Location: BR191.1; 06901/s

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Id: 9426 Author: Osawa, Nobutaka Title: Use of cycloheximide on intracellular growth of Mycobacterium leprae in cultured murine macrophages ..- Source: s.l; s.n; 1991. 8 p. ilus, tab, graf. Descriptors: TÉCNICAS BACTERIOLOGICAS CICLOEXIMIDA MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS CBA MYCOBACTERIUM LEPRAE DIVISAO CELULAR Location: BR191.1; 06375/s

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